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CRISPR Based DNA Editors

  • HuidaGene's CRISPR Cas12Max

    Cas12 is a single RNA-guided endonuclease (opposed to two RNAs by the Cas9 system), which means it processes its own guide RNAs (gRNAs) and only requires a CRISPR RNA (crRNA) for successful targeting, making it a smaller overall package than Cas9. The ability to design a targeting crRNA for both Cas9 or Cas12 is very straightforward and key to the simplicity and broad use of these systems in genome editing.


Proprietary DNA Editing Tools

  • DNA Editor - hfCas12Max / enCas12f
    •Gene knockout, exon skipping
    • Suitable for single AAV / LNP (~1050aa or ~400aa)
    •High efficiency ( in vitro >90%, in vivo ~100%)
    •Low off-target
    •Broad PAM (5’-TN)
  • DNA Base Editor - miniBE
    •Gene knockout, mutation correction (DNA base editing)
    • Suitable for single AAV / LNP (<1000aa)
    •High efficiency ( in vitro >80%)
    •Low off-target